Fenben is an antiparasitic medication that can be used to treat various types of parasites. It is a type of broad-spectrum anthelmintic that targets roundworms, hookworms, whipworms, and Taenia tapeworms. It can be found in many different forms, including powder and tablet form.
The calorimetric curves of the physical mixtures showed three endothermic peaks attributed to the respective polymer melting, while the presence of new signals in the spectra may indicate intermolecular interactions.
Antihelminthic activity
Fenbendazole is a benzimidazole anthelmintic that has been shown to be effective in the treatment of several intestinal helminths in sheep. It acts by destroying the microtubules of the worms and blocking their uptake of glucose, leading to a lack of energy for the parasite. It also has a killing effect on the eggs of the parasite.
The solubility of fenbendazole was improved by mechanochemical processing with PVP. In addition, the granularity of the powder increased, which increases surface area and porosity, enhances adsorptivity, and improves dissolubility. This method also enables it to be absorbed more easily in the gastrointestinal tract.
Small ruminants are an important source of food for many people in developing countries. However, parasitic gastroenteritis in these animals causes heavy production losses. Infection with Haemonchus contortus is a serious problem in the grazing industry, and is responsible for a large portion of helminthic disease burden worldwide. This is why the antihelmintic activity of fenbendazole is so important.
Mode of action
Fenbendazole (FZ) is a member of the broad-spectrum benzimidazole carbamate family and has been used as an anthelmintic for nearly six decades. This drug works by binding to tubulin in parasite cells, inhibiting MT polymerization and thereby disrupting microtubules. This disruption leads to the depolarization of mitochondrial membranes, resulting in a lack of energy for cell function and eventually death of the parasite.
The analytical standard fenbendazole and distilled water for HPLC were obtained from Sigma-Aldrich, and sodium dihydrogen phosphate dehydrate and hydrochloric acid were purchased from Macron Fine Chemicals. LC-MS grade methanol was also used for the analysis. Fenbendazole powder samples of three different LOT numbers from two commercial brands were dissolved in hydrochloric methanol and filtrated when necessary through a 0.45-m nylon filter for the LC-MS analysis. This characterization was performed for research purposes and is not intended for patient self-administration. The pharmacokinetics and safety of this drug should be confirmed in extensive clinical trials before use in a therapeutic context.
Dosage
Fenbendazole powder is used to treat parasites and worms in sheep, goats, cattle, pigs, carnivores, dogs, cats, and other fur-bearing animals. It also treats nematodes, cestodes, and certain types of tapeworms. It is usually well tolerated by most pets at labeled dosages, but can cause salivation or vomiting in some animals. It is often combined with other medications to maximize effectiveness.
A soluble drench can be made by dissolving one 52-gram packet in 1 quart (943 ml) of water. This solution is safer than oral administration and can provide a wider margin of safety if there are small errors in dosing.
This product is supplied for LABORATORY RESEARCH USE ONLY. Not for human use or for veterinary use. Please consult your veterinarian for proper handling and administration instructions. Keep out of the reach of children. Do not store at high temperatures.
Side effects
Fenbendazole does not typically cause side effects at labeled dosages and is considered safe to use in pregnant animals. However, hypersensitivity reactions secondary to antigen release by dying parasites may occur in rare instances. In addition, salivation, vomiting, and diarrhea can sometimes develop as a result of the medication. If these symptoms occur, veterinary care should be sought immediately.
While fenbendazole is an effective treatment for a variety of parasites, it also has been used by humans to treat cancer (known as the Joe Tippens Protocol). Regardless of your health goals, working with an integrative healthcare professional is the best way to determine whether this medication will benefit you.
For the deworming of cattle, small ruminants (sheep, goats), horses, pigs, fur animals and poultry (chickens, turkeys, geese) against roundworms, hookworms, whipworms and some tapeworms. It can also be used to treat nematodes (Ascarididae, Ascaridiidae, Ancylostomatidae, Anisakidae, Dictyocaulidae), cestodes and trematodes (Dictyocephalidae, Oxyuridae and Trichostrongylidae) in fish. fenben powder